FSP Precision Medicine Academy Virtual Tumor Board - University of Miami-video1678561602

Video Transcription

Video Summary

The Florida Society of Pathologists’ virtual tumor board showcased how collaboration among pathologists, molecular specialists, and oncologists can change cancer diagnosis and treatment.<br /><br />Four challenging cases were discussed. A 68-year-old man with a myeloid malignancy had findings initially overlapping chronic myeloid leukemia and an MDS/MPN. Molecular testing identified BCR::ABL1 and an unusual additional fusion; he was diagnosed with blast-phase CML and achieved a strong response to dasatinib. A young man with acute myeloid leukemia had WT1 and CEBPA mutations, but the CEBPA alteration did not meet criteria for a favorable defining subtype. Despite multiple therapies and transplant, his disease relapsed and he died.<br /><br />An adolescent with a bone tumor was initially thought to have Ewing sarcoma. Molecular findings and clinical history instead revealed a rare late metastatic relapse of childhood retinoblastoma. A patient with metastatic breast cancer developed an unusual bone lesion. Sequencing, including a high tumor mutational burden and an APOBEC-like mutational pattern, supported breast origin and suggested potential immunotherapy options.<br /><br />The cases emphasized that molecular results can refine or overturn morphology-based diagnoses and guide management, while multidisciplinary communication is essential to precision care.

Keywords

virtual tumor board

pathology collaboration

molecular diagnostics

cancer diagnosis

blast-phase CML

acute myeloid leukemia

retinoblastoma metastasis

breast cancer genomics

precision oncology